Although pre-tangle stage of tauopathy is regarded as an important pathogenic factor in neurodegenerative disease, their relationship with brain functional connectivity (FC) is still ambiguous. We investigated a tau mouse (rTg4510) model at 2.5 month-old age by resting-state functional MRI, spatial memory task and histopathology. We found increased FC between hippocampus and medial temporal area in rTg4510. Moreover, increased FC is negatively related to learning performance even though the memory is intact. On pathology, there is little phosphorylated tau over temporal areas. Our results suggest FC alternation may be an early sign of neural dysfunction at pre-tangle stage.
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