Abstract #2572

Spatio-temporal alterations in resting-state co-activation patterns in a rat model of sporadic Alzheimer’s disease

Yujian Diao^1,2,3, Rolf Gruetter³, and Ileana O. Jelescu^1,2

¹CIBM Center for Biomedical Imaging, Lausanne, Switzerland, ²Animal Imaging and Technology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Impaired brain glucose consumption is a possible trigger of Alzheimer’s disease (AD). Previous work revealed affected brain structure and function by insulin resistance in terms of altered static functional connectivity (FC) in an intracerebroventricular-streptozotocin (icv-STZ) rat model of AD. Here, we used the co-activation patterns (CAP) method, a dynamic FC approach, to assess differences between icv-STZ rats and healthy controls. STZ rats displayed early higher predominance of states involving brain regions shown as hyperconnected by the static FC analysis. Longitudinally, specific brain states declined in the STZ rats only.

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