Individuals with chronic HIV-infection suffer from neurocognitive impairment. These changes are thought to be mediated by atrophy and demyelination in the setting of chronic neuroinflammation. In this abstract, we used fixed-based analysis (FBA) to investigate the relationship between white matter integrity and cognitive function in the presence of HIV infection. Connectivity-based fixel ehancement and region-based statistics were performed to evaluate group differences at the fixel and tract level, respectively. Lower fixel-based metrics were observed in the HIV+ cohort. We also observed significant correlations between fixel-based metrics and cognitive scores derived from neuropsychological testing in the HIV+ cohort.
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