Abstract #1673

Assessment of brain structural connectome alterations in depressive patients with suicidal attempt using GQI

Chun-Ju Kao¹, Vincent Chin-Hung Chen^2,3, Yuan-Hsiung Tsai^3,4, and Jun-Cheng Weng^1,2,5

¹Department of Medical Imaging and Radiological Sciences, and Bachelor Program in Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, ²Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ³School of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Depression is a key factor in committing suicide. Patients with depression often accompany with brain network alterations. Three groups of participants were recruited in the study, including healthy controls (HC), depressed patients with and without suicidal attempt history (SA, D). We analyzed brain network alternations by using their GQI data. SA group showed lower global integration and higher local segregation compared to D and HC groups. Furthermore, SA and D groups had significant subnetwork connections in frontal and parietal lobes than HC group. The alternations were found in the network measurement in depressed patients with and without suicidal attempt history.

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