This study aimed to exploit the early Wallerian degeneration (WD) along the corticospinal tract following cerebral ischemic stroke using amide proton transfer weighted (APTw) and diffusion weighted imaging (DWI). This study included 34 patients with acute cerebral infarction and 21 healthy adult controls. Our data suggested that APTw and apparent diffusion coefficient (ADC) values was significantly increased on ipsilateral compared to contralateral and the control group in the posterior limb of internal capsule. It proves the feasibility of APTw and ADC in early detection of WD following cerebral ischemic stroke.
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