Abstract #0874

Assessment of Symptom Onset Time in Ischemic Stroke Patients Using Fast High-Resolution 3D 1H-MRSI

Zengping Lin¹, Tianyao Wang², Rong Guo^3,4, Yudu Li^3,4, Yibo Zhao^3,4, Tianxiao Zhang¹, Jun Liu², Xin Yu⁵, Zhi-Pei Liang^3,4, and Yao Li¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Determination of ischemic stroke onset time is critical in ischemic stroke treatment. ¹H-MRSI has been recognized as a potentially powerful tool for noninvasive metabolic imaging, which showed great promise for the assessment of stroke onset time. This study investigated changes of neurometabolite concentrations in lesion after different symptom onset time in ischemic stroke patients using a fast high-resolution 3D MRSI technique. Our results showed that NAA concentration within the ischemic lesion decreased in a time-dependent manner after stroke onset, which might provide a useful metabolic biomarker for assessment of symptom onset time.

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