This study aims to investigate spatiotemporal evolution of cerebral oxygen extraction fraction (OEF) in ischemic stroke with an MRI-based vascular-challenge-free method. The OEF of the infarcted area descends continuously from acute to chronic phase. Meanwhile, there exists tissue that is likely to be penumbra in the acute diffusion lesion, of which the OEF shows an increasing trend with time, suggesting timely reperfusion in this region. This MRI-based OEF mapping can precisely capture the heterogenous character of brain oxygen metabolism at different phases of ischemic stroke.
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