Abstract #4520

Which frontal white matter pathways mediate executive decline in healthy ageing?

Anoushka Leslie¹, Ahmad Beyh^1,2, Marco Catani³, Flavio Dell'Acqua³, Ceriesse Gunasinghe⁴, Henrietta Howells⁵, Richard Parker⁶, Andy Simmons¹, Michel Thiebaut de Schotten^7,8, Steve Williams¹, and Mitul Mehta¹

¹Department of Neuroimaging, King's College London, London, United Kingdom, ²NatBrainLab, King's College London, London, United Kingdom, ³Natbrainlab, Department of Neuroimaging, King's College London, London, United Kingdom, ⁴Department of Psychological Medicine, King's College London, London, United Kingdom, ⁵Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Universita degli studi di Milano, Milano, Italy, ⁶IXICO plc, London, United Kingdom, ⁷Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, Universite de Bordeaux, Bordeaux, France, ⁸Brain Connectivity and Behaviour Laboratory, BCBlab, Sorbonne Universities, Paris, France

This study aimed to expand our understanding of how changes to frontal white matter pathways might influence executive decline in healthy ageing. We selected three cognitive components of executive function, attention, spatial working memory and planning and predicted that changes to microstructure of the cingulum, IFOF and SLFI -III would play a mediatory role in age related cognitive decline of 86 healthy adults. Contrary to our predictions, no mediation effects were found within the proposed tract - task groupings. Instead, during exploratory analysis, HMOA of the left uncinate demonstrated a small to medium indirect effect on age-related decline in planning performance.

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