Abstract #4519

Fourier analysis of dynamic diffusion changes during cardiac cycle in idiopathic normal pressure hydrocephalus

Yuya Yasuda¹, Tosiaki Miyati¹, Naoki Ohno¹, Mitsuhito Mase², Ryo Yagawa¹, Rika Saito¹, Masatomo Uehara¹, Harumasa Kasai², Yuta Shibamoto², and Satoshi Kobayashi¹

¹Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, ²Nagoya City University Hospital, Nagoya, Japan

In this study, we evaluated the frequency characteristics of the apparent diffusion coefficient (ADC) wave form in the cardiac cycle of the brain in idiopathic normal pressure hydrocephalus (iNPH). iNPH is associated with higher ADC amplitude with a wide frequency range. The Fourier analysis of ADC change in the cardiac cycle in iNPH makes it possible to noninvasively obtain a more detailed information regarding the intracranial state in iNPH.

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