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Abstract #4521

Increased non-Gaussian subdiffusion in white matter is associated with increased longitudinal blood pressure exposure in adults at midlife

Carson Ingo1,2, Shawn Kurian3, James Higgins4, Lisanne Jenkins5, Donald Lloyd-Jones6, and Farzaneh Sorond1
1Department of Neurology, Northwestern University, Chicago, IL, United States, 2Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, 3Department of Neurology, Chicago, IL, United States, 4Department of Radiology, Northwestern University, Chicago, IL, United States, 5Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, United States, 6Department of Preventative Medicine, Northwestern University, Chicago, IL, United States

The increased presence of non-Gaussian subdiffusive dynamics, possibly reflecting the presence of increased neuronal and glial microstructural heterogeneity, is sensitive increased vascular risk exposure, which was not observed with traditional DTI metrics such as FA.

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