Abstract #3094

Investigation of Optimizing Chemical Exchange Saturation Transfer Imaging for Tuberous Sclerosis Epilepsy at 3 Tesla

Qingqing Wen¹, Kang Wang², Yi-Cheng Hsu³, Yi Sun³, Dan Wu^1,2, and Yi Zhang^1,2

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Neurology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China, ³Siemens Healthcare Ltd., Shanghai, China

Epilepsy is a prevalent neurological manifestation of Tuberous Sclerosis Complex (TSC). Here, the feasibility of applying Chemical Exchange Saturation Transfer (CEST) imaging to TSC epilepsy is investigated, with the radio-frequency saturation power, duration and frequency offsets optimized. The maximum CEST contrast between cortical tubers and normal white matter was achieved for an optimal saturation duration of 1000ms, while the optimal saturation frequency offset was related to the saturation power. Importantly, distinct contrast between tubers and normal white matter was demonstrated for TSC epilepsy for the first time, indicating CEST may serve as a potentially useful tool for diagnosing TSC.

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