Abstract #3093

Protein-sensitive CEST-MRI of Alzheimer’s patients at 3 T

Steffen Goerke¹, Johannes Breitling¹, Katharina M. Kubera², Moritz Zaiss³, Dusan Hirjak⁴, Robert C. Wolf², Anoshirwan A. Tavakoli⁵, Heinz-Peter Schlemmer⁵, Daniel Paech⁵, Mark E. Ladd¹, and Peter Bachert¹

¹Divsion of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Center for Psychosocial Medicine, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany, ³Neuroradiology, University of Erlangen-Nürnberg, Erlangen, Germany, ⁴Departement of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁵Departement of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, the potential of CEST-MRI as a tool for diagnostic imaging of Alzheimer’s patients was evaluated. Although the study size was yet too small to draw final conclusions, a significant decrease of the rNOE-CEST signal in Alzheimer’s patients was observed. This finding was in line with previous in vitro studies on the monitoring of protein aggregation using CEST-MRI. A diagnostic tool for Alzheimer’s based on CEST-MRI would allow avoiding invasive examinations and thus more frequent follow-ups allowing an improved level of patient care.

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