Tubular hypertrophy is an early feature of many renal pathologies. A direct, non-invasive measure of kidney morphology is lacking. Current diagnostics are primarily based on biopsy after suspected renal disease, which is prone to sampling error and is invasive. A robust non-invasive imaging tool to study tubular changes in vivo is greatly needed and would provide early tissue biomarker for initiation and progression of kidney injury. In this work, we used a single diffusion encoding MRI approach to study distribution of restricting tissue compartment sizes in kidney cortex as a potential noninvasive marker of tubule size in the intact kidney.
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