Abstract #2460

Spin-lock MRI Reveals Tubular Dilation and Fibrosis after Unilateral Ureter Obstruction

Feng Wang^1,2, Tadashi Otsuka³, Keiko Takahashi³, Daniel C. Colvin¹, Hua Li¹, Raymond C. Harris³, Takamune Takahashi³, and John C. Gore^1,2,4

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Assessing the severity and progression of tubular dilation and fibrosis in kidneys are important clinical challenges. Here we evaluate spin-lock MR imaging with different locking fields for detecting tubular dilation and fibrosis in a mouse model of unilateral ureter obstruction. We fit the dispersion of spin-lock relaxation rates R_1ρ at different locking fields (frequencies) to a model of exchanging water pools and assessed the sensitivity of the derived quantities for detecting tubular dilation and fibrosis in kidney. Histological scores for tubular dilation and fibrosis, based on luminal space and positive picrosirius red area in sections, were obtained for comparison.

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