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Abstract #1936

Longitudinal brain connectome reorganization in a tauopathy mouse model of Alzheimer's disease

Laetitia Degiorgis1, Marion Sourty1,2, Julien Lamy1, Vincent Noblet1, Meltem Karatas1,3,4, Thomas Bienert4, Marco Reisert4, Anne-Laurence Boutillier5, Jean-Paul Armspach1, Frédéric Blanc1,6, and Laura Harsan1,7
1University of Strasbourg and CNRS, ICube Laboratory UMR 7357, Strasbourg, France, 2The University of Sydney, Faculty of Engineering, School of Aerospace, Mechanical and Mechatronic Engineering, Sydney, Australia, 3CNRS, University of Strasbourg, INCI, UMR 7168, Strasbourg, France, 4Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 5Laboratoire de Neuroscience Cognitives et Adaptatives, Strasbourg, France, 6University Hospital of Strasbourg, CM2R (Memory Resource and Research Centre), Day Hospital, Geriatrics Department, Strasbourg, France, 7Department of Biophysics and Nuclear Medicine, University Hospital of Strasbourg, Strasbourg, France

MRI is a unique tool to understand the complexity of the brain functional and structural communication evolution over time. Among the main mechanisms of AD, tauopathy remains poorly studied in preclinical imaging. We used graph theory approaches and DTI analysis in a longitudinal study of Thy-Tau22 mice, associated with behavioral evaluation. Alterations of the cholinergic septal circuitry, supporting memory and emotional processes, were found as the main hallmark of the progression of the pathology, associated with default mode network dysfunction, both starting before the first memory deficits.

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Abstract