The main objective of this study is to modulate and map the anterior cyngulate cortex (ACC) functional connectivity (FC) pathways underlying depression development in a mouse model. We use the optogenetic approaches to create the depression phenotype in mice, by activating the pyramidal ACC neurons expressing Channel rhodopsin 2 (ChR). We further use resting state functional MRI (rsfMRI) as non-invasive read-out of the effects at the level of functional brain connectivity. Four consecutive sessions of optogenetic ACC stimulation induced strong depression phenotype and major modifications of the functional mouse brain connectivity including perturbed mesocorticolimbic pathways and default mode network patterns
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