Abstract #1935

Functioning of the glucose transporter and glymphatic systems in the tauopathy AD mouse brain studied by onVDMP MRI and D-glucose infusion

Lin Chen^1,2, Zhiliang Wei^1,2, Kannie W.Y. Chan^1,2,3, Jianpan Huang⁴, Xiang Xu^1,2, Philip C. Wong^5,6, Hanzhang Lu^1,2, Peter C.M. van Zijl^1,2, Tong Li^5,6, and Jiadi Xu^1,2

¹Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ⁴City University of Hong Kong, Hong Kong, China, ⁵Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States

In this study, we used onVDMP MRI to detect glucose uptake in tauopathy Alzheimer's disease (AD) mouse brain. Compared to wild-type mice, significantly reduced glucose uptake was observed in both cerebrospinal fluid (CSF) and parenchyma of AD mouse brain. Clearance of glucose through CSF was found in wild-type mice, but not in AD mice, which implicates dysfunction of the glymphatic system in AD mouse brain. The results in this study suggest that onVDMP MRI could be a cost-effective and widely available method for evaluating the functions of glucose transporter and glymphatic system, and hence diagnosing AD.

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