Numerous methods have been proposed to overcome the confounding influence of contrast agent leakage on DSC-MRI derived CBV maps in brain tumors. Recently, we leveraged a digital reference object to identify the optimal acquisition and analysis methods for GBM patients, a protocol that is now being recommended as the standardized approach for all clinical scans. It is unknown if the biological differences between GBM and metastases would confound the use of this protocol in patients with brain metastases. In this study we characterize the influence of this GBM-centric protocol resulted in lower metastases CBV accuracy and precision.
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