Current recommendations for brain tumor dynamic susceptibility contrast MRI include the use of a moderate flip angle (MFA) and a full standard preload dose.1 Recently, simulations2 identified an equally accurate protocol that requires no preload and uses a low flip angle (LFA) and optimized echo time. This was validated in vivo3 by comparing LFA- and MFA-based mean tumor cerebral blood volume. Here we aim to systematically characterize agreement by evaluating the pixel-wise agreement in enhancing tumor, edema, white matter, and gray matter regions. We found high agreement in all regions further strengthening the clinical utility of the LFA protocol.
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