Abstract #0690

Assessment of Intracranial Metastases in Patients using Hyperpolarized 13C MRI

Casey Y Lee^1,2, Hany Soliman³, Benjamin J Geraghty^1,2, Nadia D Bragagnolo^1,2, Albert P Chen⁴, William J Perks⁵, Arjun Sahgal³, Michael W Chan⁶, Sean Symons⁷, and Charles H Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴GE Healthcare Technologies, Toronto, ON, Canada, ⁵Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Diagostic Imaging, Trillium Health Partners, Mississauga, ON, Canada, ⁷Radiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Hyperpolarized ¹³C MRI was used to acquire images of [1-¹³C]lactate and ¹³C-bicarbonate from the injected [1-¹³C]pyruvate in 8 patients with brain metastases. Lesions were manually contoured and the mean tumor ¹³C-lactate signal was converted to a z-score by extending the approach previously described in Lee et al. (2019). As expected, the z-score ranks of the anatomical regions were less concordant in patients compared to controls. A range of lactate z-scores were observed in metastatic lesions, showing metabolic heterogeneity consistent with the known heterogeneity in metastatic features and clinical status. The lesions with the highest and 5^th highest lactate z-scores progressed.

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