Abstract #0689

Metabolism of the hyperpolarized neuroprotective agents [1-13C] lactate and [1-13C] pyruvate in a mouse model of transient ischemic stroke

Thanh Phong Lê^1,2, Lara Buscemi³, Elise Vinckenbosch¹, Mario Lepore⁴, Lorenz Hirt³, Jean-Noël Hyacinthe^1,5, and Mor Mishkovsky²

¹Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland, ²Laboratory of Functional and Metabolic Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ³Department of Clinical Neurosciences, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁴Center for Biomedical Imaging - Animal Imaging and Technology (CIBM-AIT), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵Image Guided Intervention Laboratory, University of Geneva (UNIGE), Geneva, Switzerland

Stroke is a major cause of death and disability. Neuroprotective strategies could ameliorate patient recovery. Pyruvate and lactate were found neuroprotectant in preclinical studies of stroke models. Hyperpolarized ¹³C MRI provides a new way for real-time molecular imaging. In this work, we hyperpolarize those neuroprotective agents to study changes of their metabolism when administered at their therapeutic dose after ischemic stroke. We found that the metabolism of hyperpolarized lactate is significantly altered after transient cerebral ischemia, whereas moderate changes were depicted with hyperpolarized pyruvate. Those imply that hyperpolarized lactate would potentially be a better theranostic biosensor for stroke.

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