Abstract #4142

Feasibility of Single Breath-hold Isotropic Voxel 129Xe MRI in Patients

Andrea L Barker^1,2, Andrew L Westcott^1,2, Rachel L Eddy^1,2, David G McCormack³, Grace Parraga^1,2,3, and Alexei L Ouriadov¹

¹Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Division of Respirology, Department of Medicine, Western University, London, ON, Canada

Hyperpolarized ¹²⁹Xe gas MRI has been established as an effective tool to investigate lung function in a number of pulmonary diseases. Improved ¹²⁹Xe polarization techniques provide the opportunity to use a high-resolution 3D static ventilation image acquisition sequence (FGRE) in a 16-second breath-hold. Isotropic-voxel images were acquired in one healthy-volunteer and two patients with asthma; images were compared to coronal images acquired in two other patients with asthma. Isotropic images had sufficient SNR to analyze VDP. This proof-of-concept investigation establishes the feasibility of using an isotropic-voxel acquisition sequence in single breath-hold MRI of the lungs.

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