Abstract #4141

Mapping and Correcting Hyperpolarized Magnetization Decay Using Radial Keyhole Imaging

Peter J Niedbalski¹, Matthew M. Willmering¹, Scott H. Robertson², Matthew S. Freeman¹, Wolfgang Loew³, Randy O. Giaquinto³, Christopher Ireland^3,4, Ronald G. Pratt³, Charles L. Dumoulin^3,4,5, Jason C. Woods^1,3,5, and Zackary I. Cleveland^1,3,4,5

¹Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Clinical Imaging Physics Group, Department of Radiology, Duke University Medical Center, Durham, NC, United States, ³Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁴Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, ⁵Department of Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH, United States

Hyperpolarized (HP) media enable biomedical imaging applications otherwise unachievable using standard MRI contrast agents. However, quantitative analysis of HP images is complicated by spatially varying signal decay due to T₁ relaxation and RF excitation. By imaging with center-out trajectories, HP signal intensity is collected with every acquisition, thereby encoding signal decay alongside k-space data. Using keyhole reconstruction, multiple temporally resolved images were reconstructed to generate voxel-by-voxel maps of hyperpolarized signal decay following a simple analytical model. Here these maps are applied to correct spatially varying magnetization decay in HP ¹²⁹Xe, improving the quantitative accuracy of ventilation images.

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