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Abstract #4135

Accelerated Spiral-IDEAL for Gas and Dissolved Phase Hyperpolarized 129Xe in the Lungs of Healthy Human Volunteers:  Effect of k-space Calibration Data on Image Quality and Gas Exchange Analysis

Brandon Zanette1 and Giles Santyr1,2

1Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada

Parallel imaging with multi-channel receivers provides flexible acceleration of scan duration and is an important tool in both clinical and research settings. The application of parallel imaging to hyperpolarized 129Xe MRI may be useful in improving the clinical utility of parametric gas exchange mapping by reducing breath-hold durations or allowing for the acquisition of additional temporal/spatial information. In this work, we investigate the effect of k-space calibration data on parallel imaging reconstruction of time-resolved measurements of hyperpolarized 129Xe uptake using spiral-IDEAL and quantify resultant changes in the estimation of lung physiology.

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