Abstract #4134

Compressed Sensing Hyperpolarized Noble Gas Ventilation MRI: Towards a Maximum Clinically Acceptable Acceleration Factor

Andrew Westcott^1,2, Alexei Ouriadov¹, Rachel L Eddy^1,2, David G McCormack³, Miranda Kirby⁴, and Grace Parraga^1,2,3

¹Robarts Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³Division of Respirology, Department of Medicine, Western University, London, ON, Canada, ⁴Department of Physics, Ryerson University, Toronto, ON, Canada

Compressed sensing has been applied to hyperpolarized gas MRI to accelerate acquisition and allow for increased data or resolution. To better understand the effect of compressed sensing on biomarkers derived from static ventilation images, data were retrospectively undersampled in 10 individuals with chronic obstructive pulmonary disease and k-means clustering was performed. Raw reconstruction resulted in differences less than the ventilation defect percent minimal clinically important difference up to an acceleration factor of 3. The total variation Split-Bregman reconstruction resulted in qualitatively adequate images, however, further optimization of regularized reconstruction techniques is required to achieve consistent ventilation signal clustering.

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