Ventilation MRI using hyperpolarised gases is highly sensitive to early cystic fibrosis lung disease. With the recent move towards 129Xe from 3He, we aimed to assess both gases in parallel in patients with CF, at baseline and follow-up, to determine whether any inherent bias was present when assessing lung disease. We found that there was no inherent bias for VDP between the two gases present although at an individual level differences were evident. Despite this, when followed up at a later date both gases similarly reflected changes in ventilation, suggesting both are capable of reflecting CF lung disease severity.
This abstract and the presentation materials are available to members only; a login is required.