Abstract #3308

Phase imaging and serum neurofilaments: a combined laboratory-imaging marker of multiple sclerosis chronic inflammation

Pietro Maggi¹, Martina Absinta², Amandine Mathias³, Pascal Sati², Caroline Pot¹, Reto Meuli⁴, Jens Kuhle⁵, Ludwig Kappos⁵, Du Pasquier Renaud¹, Daniel S. Reich², and Cristina Granziera^5,6

¹Department of Neurology, Lausanne University Hospital, Lausanne, Switzerland, ²Translational Neuroradiology Section/NINDS, National Institutes of Health, Bethesda, MD, United States, ³Laboratory of Neuroimmunology, Lausanne University Hospital, Lausanne, Switzerland, ⁴Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland, ⁵Department of Neurology, Basel University Hospital, Basel, Switzerland, ⁶Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engeneering, Basel University Hospital, Basel, Switzerland

In multiple sclerosis (MS), persistent chronic inflammation at the edges of old non-gadolinium-enhancing white matter lesions, is identified with a paramagnetic rim on susceptibility-based-MRI sequences. Serum neurofilaments (sNfL) levels are associated with disease activity and neurodegeneration in acute and chronic phases of MS. Whether the presence of chronic inflammation is accompanied by increased in neuroaxonal destruction is currently unknown. We showed that MS patients featuring chronic inflammation at the lesions edges have higher neuroaxonal destruction than patients without. The combination of paramagnetic rim and sNfL may help in the selection of “chronically” active MS patients who may benefit from disease-modifying-treatments.

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