Abstract #3307

Utilizing QSM to assess long-term longitudinal susceptibility changes in enhancing multiple sclerosis lesions

Shun Zhang^1,2, Thanh D. Nguyen², Sandra Milena Hurtado Rua³, Yi Wang^2,4, and Susan A. Gauthier⁵

¹Radiology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China, ²Radiology, Weill Cornell Medical College, New York, NY, United States, ³Mathematics, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, United States, ⁴Biomedical Engineering, Cornell University, Ithaca, NY, United States, ⁵Neurology, Weill Cornell Medical College, New York, NY, United States

We measured the longitudinal susceptibility change of 32 new Gd-enhancing lesions from 19 multiple sclerosis (MS) patients over six years. Lesion susceptibility increased to peak within 1-2 years and was followed by a steady decline. Lesions with QSM rim had an overall higher susceptibility and demonstrated a decay rate that was significantly slower compared to that of lesions without rim.

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