Abstract #3309

Multi-Parametric White Matter Imaging in Multiple Sclerosis Lesions

Ewart Mark Haacke^1,2,3, Evanthia Bernitsas⁴, Karthikeyan Subramanian¹, David T Utriainen^2,3, Vinay Kumar⁵, Sean Kumar Sethi^2,3, Yongsheng Chen^1,2, Zahid Latif¹, Pavan Kumar¹, Xiomeng Zheng⁶, Robert A Comley⁶, and Yanping Luo⁶

¹Wayne State University, Detroit, MI, United States, ²The MRI Institute for Biomedical Research, Bingham Farms, MI, United States, ³Magnetic Resonance Innovations Inc., Bingham Farms, MI, United States, ⁴Multiple Sclerosis Center, Wayne State University School of Medicine, Detroit, MI, United States, ⁵MR Medical Imaging Innovations Inc., Hyderabad, India, ⁶AbbVie, North Chicago, IL, United States

A multiparametric quantitative white matter study using MRI was designed to include 15 relapsing remitting MS patients and 10 age and sex matched controls. The imaging protocol acquired 3D conventional imaging, SWI, QSM, DTI, MTC, and STrategically Acquired Gradient Echo (STAGE) imaging. ROI were manually drawn around MS lesions in T2-FLAIR and QSM. Contralateral normal appearing white matter (NAWM) and NAWM in controls were drawn in all modalities to measure mean intensity and volume. We found a good correlation between QSM, MTR, FA, MWF and conventional imaging. QSM’s sensitivity to demyelination best complimented T2-FLAIR’s sensitivity to inflammation and scarring.

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