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Abstract #2546

Longitudinal cerebral metabolic changes in delayed neurologic sequelae after carbon monoxide intoxication using 1H MR spectroscopy.

Hui-ru Tsai1, Jung-Hsiang Chang1, Ping-Hong Lai2,3, Jie-Yuan Li4,5, and Cheng-Wen Ko1

1Dept. of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan, 2Dept. of Radiology, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan, 3School of Medicine, National Yang-Ming University, Taipei, Taiwan, 4Dept. of Neurology, E-Da Hospital, Kaohsiung, Taiwan, 5School of Medicine, I-Shou University, Kaohsiung, Taiwan

In this study, we explored the metabolic changes in WM and GM of patients with and without DNS using 1H MRS longitudinally at onset, 1, 3, and 9 months after CO intoxication. Decreased tNAA/Cr and increased Cho/Cr were observed in WM of patients with DNS as literatures have reported. The longitudinal change of Glx/Cr and Ins/Cr in WM and GM of patients with DNS implies themselves that may provide valuable information for monitoring DNS development.

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