Abstract #2545

Metabolic Alterations in the left dorsolateral prefrontal cortex in Sleep-Related Hypermotor Epilepsy: A Proton Magnetic Resonance Spectroscopy Study

Weina Wang¹, Xiaorui Su¹, Simin Zhang¹, Qiang Yue², and Qiyong Gong¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Department of Radiology, West China Hospital of Sichuan University, Chengdu, China

Sleep-Related Hypermotor Epilepsy (SHE) is characterized by bizarre motor behavior during sleep. The aim of this present study was to investigate metabolic alterations in the bilateral DLPFC using ¹H-MRS to understand the underlying pathophysiology of SHE. Thirty-nine subjects with SHE and 60 controls were studied. The left DLPFC NAA and mI concentrations of SHE patients were significantly lower than controls. There was an asymmetry of NAA in the control group. These findings may present executive function decline in SHE and further verify the left frontal lobe is more vulnerable in right-handed SHE patients.

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