Abstract #0500

Dextran-based CEST MRI for detecting extradomain-B fibronectin in pancreatic cancer

Jiaqi Lu¹, Zheng Han², Jia Zhang², Yuguo Li², Jing Liu², Kenji Fujiwara³, Peter van Zijl², Lei Zhang³, and Guanshu Liu^2,4

¹Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ³Department of Oncology, Johns Hopkins University, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institue, Baltimore, MD, United States

A dextran-peptide conjugate was developed for MR molecular imaging of pancreatic ductal adenocarcinoma (PDAC) through its overexpressed microenvironment biomarker, extradomain-B fibronectin (EDB-FN). Dextrans can be directly detected by chemical exchange saturation transfer (CEST) MRI without the need for radionuclide- or metallic labeling. In addition, large molecular weight dextran, dextran 10 (MW~ 10 kD), provides an approximately fifty times higher sensitivity per molecule than a single glucose unit. The potential of this highly biocompatible diamagnetic probe is demonstrated in a murine syngeneic allograft PDAC tumor model.

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