Pancreatic ductal adenocarcinoma (PDA) is characterized by excessive levels of hyaluronan and collagen, resulting in a dense fibroinflammatory stroma that inhibits penetration of chemotherapeutic drugs into the tumor. Pulsed focused ultrasound (pFUS) treatment has shown promising results in disrupting the dense stroma and reducing the interstitial fluid pressure of PDA. The purpose of this study is to noninvasively assess response to pFUS treatments using quantitative MRI and to correlate the MRI results with histopathology data.
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