Abstract #5431

Differential effects of hunger and depression on cerebral blood flow in healthy adolescents

Céline Charroud^1,2, Emmanuelle Le Bars², Emily Sanrey^1,3, Jérémy Deverdun², Josef Pfeuffer⁴, Nicolas Menjot de Champfleur², and Philippe Coubes^1,3

¹Unité de recherche sur les comportements et mouvements anormaux (URCMA, IGF, INSERM U661 UMR 5203), Departments of neurosurgery, Montpellier University Hospital Center, Gui de Chauliac Hospital, University of Montpellier, Montpellier, France, ²Institut d’Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, University of Montpellier, Montpellier, France, ³Unité de pathologie cérébrale résistante, Department of neurosurgery, Montpellier University Hospital Center, Montpellier, France, ⁴Siemens Healthcare GmbH, Application Development, Erlangen, Germany

This study aims to explore the appetite effect on taste and depression on healthy adolescents using Arterial Spin Labeling. Fifteen participants complete the Multiscore Depression Inventory for Children test and two MRI sessions: pre-lunch (hunger) and post-lunch (satiety). We found an increased CBF – cerebral blood flow – during hunger in the posterior insula (anticipation and motivation of feeding) and during satiation in the precuneus, lingual gyrus and cuneus (inhibition pattern of food intake). We show that the correlations between depression and CBF are modulated by appetite in the precuneus, operculum, lingual, cuneus, middle frontal gyrus and inferior parietal lobule.

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