Abstract #5432

Influences of the Gut Microbiome on Early Brain Development

Douglas C Dean¹, Elizabeth M Planalp^1,2, Nicholas Vogt³, Kristin Dowe^1,2, Alysha Rameshk¹, Kristine Mclaughlin¹, Abigail Freeman¹, and Andrew L Alexander^1,4,5

¹Waisman Center, University of Wisconsin Madison, Madison, WI, United States, ²Psychology, University of Wisconsin Madison, Madison, WI, United States, ³Medicine, University of Wisconsin Madison, Madison, WI, United States, ⁴Psychiatry, University of Wisconsin Madison, Madison, WI, United States, ⁵Medical Physics, University of Wisconsin Madison, Madison, WI, United States

Increasing evidence from animal studies suggests the gut microbiome has a significant role on early brain development and function. However, little is known about this role on human brain development and in particular, on myelination. Using quantitative multicomponent relaxometry and 16S rRNA sequencing, we examined measures of myelin content and the gut microbiome from a cohort of typical developing infants. Infant brain measures were found to be differentially associated with the relative abundancies of certain bacteria phylum, suggesting that microbial communities may have a significant influence on processes of early brain development.

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