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Abstract #5430

In vivo 1H NMR spectroscopy study of  mitochondrial pyruvate carrier 1 (MPC1) deficient mouse reveals energy shift in the development of embryonic brain

Hongxia Lei1,2, Zeinab Ammar2, Corina M Berset1, and Jean-Claude Martinou2

1Center for Biomedical Imaging (CIBM-AIT), École Polytechnique Fédérale de Lausanne, Lasuanne, Switzerland, 2University of Geneva, Geneva, Switzerland

Pyruvate degradation is an important step for oxidative phosphorylation. We studied brains of murine embryos devoid of mitochondrial pyruvate carrier 1 (MPC1) using 1H MRS. We demonstrates that after the embryonic energy shift, lactate accumulation can explain embryonic lethality in embryo devoid of MPC1.

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