Abstract #3565

Comparison between 8- and 32-channel phased-array receive coils for in vivo hyperpolarized C-13 brain imaging

Adam Autry¹, Jeremy W Gordon¹, Lucas Carvajal¹, Ilwoo Park², Daniele Mammoli¹, Hsin-Yu Chen¹, Susan Chang³, Yan Li¹, Duan Xu¹, Daniel Vigneron¹, and Sarah J Nelson^1,4

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Radiology, Chonam National University Medical School and Hospital, Chonam, Republic of Korea, ³Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, United States, ⁴Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States

This study sought to evaluate the performance of the first 32-channel head coil for in vivo hyperpolarized ¹³C brain imaging by comparison against a conventional 8-channel receiver array. Initial phantom experiments characterized the B₁+ homogeneity and SNR profiles associated with each hardware configuration via EPI-based imaging techniques. As part of a clinical trial, in vivo dynamic EPI data were also acquired from patients with brain tumors. Phantom and patient data revealed improved uniformity, coverage, and SNR with the 32-channel array that will promote higher resolution and acceleration. In vivo data also demonstrated unprecedented detection of bicarbonate using both hardware platforms.

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