Abstract #3564

Modeling In Vivo Metabolism of Hyperpolarized Pyruvate in Human Brain Tumor Patients.

Daniele Mammoli¹, Jeremy Gordon¹, Adam Autry¹, Peder EZ Larson¹, Hsin-Yu Chen¹, Mark Van Criekinge¹, Lucas Carvajal¹, Ilwoo Park², James B Slater¹, Robert Bok¹, Jason Crane¹, Markus Ferrone³, John Kurhanewicz¹, Susan Chang⁴, and Daniel B Vigneron¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Chonam National University Medical School and Hospital, Chonam, Korea, Democratic People's Republic of, ³Clinical Pharmacy, University of California San Francisco, San Francisco, CA, United States, ⁴Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

We show preliminary results of hyperpolarized [1-¹³C]pyruvate injected in 9 patients affected with glioma.

Raw data showed excellent SNR. Variable bolus delivery and magnitude images introduced errors in modeling the conversion of pyruvate into lactate: kinetic models were presented and compared quantitatively to address these issues.

Finally, reliable and spatially-resolved maps of k_PL rates were obtained, which can be useful in future to assess the clinical relevance of the method for both diagnosis and response to therapy.

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