Abstract #2248

High-resolution total Creatine mapping of the mouse brain at 11.7T using CEST

Lin Chen^1,2,3, Zhiliang Wei^1,2, Xiang Xu^1,2, Yuguo Li^1,2, Shuhui Cai³, Guanshu Liu^1,2, Hanzhang Lu^1,2, Peter B. Barker^1,2, Robert G. Weiss¹, Peter C.M. van Zijl^1,2, and Jiadi Xu^1,2

¹Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Electronic Science, Xiamen University, Xiamen, China

A combined polynomial and Lorentzian Fitting (PLOF) scheme was developed to map total creatine (tCr) signal using a CW-CEST sequence under short saturation time situation. At 11.7T, the guanidinium proton signals of tCr and tissue proteins are not coalesced with the water signal and the line-shape fitting procedure can correct the direct saturation and magnetization transfer contrast introduced spill-over effects, allowing the guanidinium CEST signal to be extracted and subsequently quantified. A series of Cr phantom and mouse brain studies with different saturation times and powers were carried out to determine the optimal parameters for protein-signal corrected creatine CEST quantification.

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