Abstract #2249

Low power Z-spectrum analysis for isolated NOE and amide CEST-MRI at 3T with comparison to 9.4T

Anagha Deshmane¹, Moritz Zaiss¹, Benjamin Bender², Tobias Lindig², Johannes Windschuh³, Kai Herz¹, and Klaus Scheffler¹

¹High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Diagnostic & Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany, ³Center for Biomedical Imaging, New York University Langone Health, New York, NY, United States

A snapCEST sequence was optimized for imaging of protein CEST effects at 3T with low saturation power. Full Z-spectrum sampling allows Lorentzian fitting of amide, NOE, semisolid MT, and water pools. Validation against data acquired at 9.4T demonstrates effective labeling of selective amide and NOE CEST effects at 3T. Data acquired in a brain tumor patients demonstrates clinical feasibility.

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