Abstract #2247

gagCEST on patients with focal knee cartilage defects

Markus M. Schreiner^1,2, Vladimir Mlynarik^2,3, Stefan Zbyn^2,4, Vladimir Juras², Pavol Szomolanyi², Didier Laurent⁵, Celeste Scotti⁵, Harry Haber⁵, and Siegfried Trattnig^2,3

¹Department of Orthopedics, Medical University of Vienna, Vienna, Austria, ²High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ³CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ⁴Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ⁵Novartis Institutes for Biomedical Research, Basel, Switzerland

The gagCEST technique is a promising tool for determining concentration of glycosaminoglycans in articular cartilage. In this study, the performance of gagCEST in a group of patients with ICRS grade I-II knee cartilage defects was investigated. It was found that the method gives significantly different mean MTR_asym values for cartilage defects, normal weight-bearing and normal non-weight-bearing femoral cartilage. The clinical use of the gagCEST technique is currently limited by its long measurement time and sensitivity to patient motion.

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