Abstract #0855

Validation of Cerebrovascular Reactivity by Arterial Spin Labeling MRI in Moyamoya Disease with Simultaneously Measured 15O-PET and Phase-contrast MRI

Yosuke Ishii^1,2, Thoralf Thamm¹, Jia Guo¹, Mohammad Mehdi Khalighi³, Mirwais Wardak¹, Dawn Holley¹, Harsh Gandhi¹, Jun Hyung Park¹, Bin Shen¹, Gary K Steinberg⁴, Fred T Chin¹, Greg Zaharchuk¹, and Audrey Peiwen Fan¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan, ³Applied Science Lab, GE Healthcare, Menlo Park, CA, United States, ⁴Neurosurgery, Stanford University, Stanford, CA, United States

We validated cerebrovascular reactivity (CVR) in Moyamoya disease measured by arterial spin labeling (ASL) simultaneously with ¹⁵O-positron emission tomography (PET) using hybrid PET/MRI scanner. We compared the three types of ASL including standard-delay, multi-delay with extended post-label delay, and velocity selective ASL (VS-ASL). To quantify absolute PET cerebral blood flow (CBF) without arterial blood samples, we scaled the static PET maps using simultaneously collected phase-contrast (PC) MRI. Multi-delay ASL showed the strongest correlation with PC-PET on both baseline and post-ACZ CBF (R² = 0.48 and 0.66 respectively). Multi-delay ASL and VS-ASL showed similar good correlations with PC-PET on CVR.

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