Even when focal, brain lesions have local and remote effects that impact functionally and structurally connected circuits. We developed a free open-source software (BCBtoolkit) that gathers different methods to estimate these effects on structural (using healthy controls tractography) and functional networks, using T1-images and fMRI data, and relate them to behavioral impairment. We applied these methods to 37 patients with a chronic focal brain lesion and 54 healthy controls in the context of category fluency. Our methods revealed a large set of directly and indirectly disconnected brain regions that had significantly impacted the performance.
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