Abstract #0856

Adaptations in cerebral physiology due to chronic anaemia measured with Turbo-QUASAR ASL

Lena Vaclavu¹, Moss Y Zhao², Esben Thade Petersen³, John C Wood⁴, Henk JMM Mutsaerts^1,5,6, Charles B Majoie¹, Ed T vanBavel⁷, Bart J Biemond⁸, Michaell A Chappell², and Aart J Nederveen¹

¹Radiology & Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, ²Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ³Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ⁴Cardiology and Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, ⁵Kate Gleason College of Engineering, Rochester Institute of Technology, Rochester, NY, United States, ⁶Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ⁷Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, ⁸Haematology, Internal Medicine, Academic Medical Center, Amsterdam, Netherlands

In this work, we applied a novel ASL method (Turbo-QUASAR) to evaluate the effects of life-long anaemia on cerebral physiology by comparing patients with Sickle Cell Disease to healthy controls. Turbo-QUASAR enables simultaneous assessment of cerebral blood flow (CBF), cerebral blood volume (aCBV) and arterial transit time (ATT) as well as tissue T1 and M0. We found normal ATT in the presence of elevated CBF in patients. In addition we found increased aCBV in patients. Acetazolamide administration shortened ATT with no change in aCBV suggesting maximal dilation and reserves being accessed by faster ATT. aCBV was inversely related to haemoglobin.

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