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Abstract #0503

Multi-parametric MRI data fusion reveals acute and persistent brain changes in concussed female varsity rugby players

Kathryn Y. Manning1,2, Alberto Llera3, Robert Bartha1,2, Gregory A. Dekaban4,5, Christy Barreira4, Arthur Brown 4,6, Lisa Fischer7, Tatiana Jevreomvic7, Kevin Blackney4, Timothy J. Doherty8, Douglas D. Fraser9, Jeff Holmes10, Christian F. Beckmann3,11,12, and Ravi S. Menon1,2

1Medical Biophysics, Western University, London, ON, Canada, 2Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada, 3Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands, 4Molecular Medicine, Robarts Research Institute, London, ON, Canada, 5Microbiology and Immunology, Western University, London, ON, Canada, 6Anatomy and Cell Biology, Western University, London, ON, Canada, 7Primary Care Sport Medicine, Fowler Kennedy Sport Medicine, London, ON, Canada, 8Physical Medicine and Rehabilitation, Western University, London, ON, Canada, 9Paediatrics Critical Care Medicine, London Health Sciences Centre, London, ON, Canada, 10Occupational Therapy, Western University, London, ON, Canada, 11Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands, 12Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, United Kingdom

Multi-parametric 3T MRI data was acquired in female varsity rugby players during the in- and off-season and compared to concussed teammates acutely (24-72 hours) and longitudinally (3- and 6-months) after a mild traumatic brain injury (mTBI). Using linked independent component analysis, we found acute and prolonged resting state functional connectivity and diffusion white matter microstructure changes that persisted beyond symptomatic recovery and clearance to return to play. These fused components also significantly correlated with aspects of concussion history and were robust and consistent across model orders and within individual concussed athletes longitudinally.

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