Abstract #0502

Assessment of white matter anisotropy effects in mq-BOLD based mapping of relative Oxygen Extraction Fraction

Stephan Kaczmarz^1,2, Jens Goettler^1,2, Andreas Hock³, Dimitrios Karampinos⁴, Claus Zimmer¹, Fahmeed Hyder^2,5, and Christine Preibisch^1,6

¹Department of Neuroradiology, Technical University of Munich, Munich, Germany, ²Department of Radiology & Biomedical Imaging, Yale University, New Haven, CT, United States, ³Philips Healthcare, Hamburg, Germany, ⁴Departement of Radiology, Technical University of Munich, Munich, Germany, ⁵School of Engineering & Applied Science, Yale University, New Haven, CT, United States, ⁶Clinic for Neurology, Technical University of Munich, Munich, Germany

Anisotropy effects were proven to strongly affect T₂* and DSC-measurements, however influences on the relative Oxygen Extraction Fraction (rOEF) by multi-parametric quantitative BOLD (mq-BOLD) have not been investigated yet. Therefore, we present a methodolocigal study within healthy elderly. The major aim was to evaluate anisotropy effects on rOEF and all mq-BOLD related parameters at the same time. We found strong orientation dependencies of T₂*, T₂, R₂' and rCBV on the main-nerve-fiber orientation towards B₀ with variations up to 26.6%. However, our results show rather low angle dependency of rOEF with 13.6% as R₂’ and rCBV effects show partially counteracting influences.

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