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Abstract #0504

Chronic Neurovascular Dysfunction in a Mouse Model of Repeated Mild Traumatic Brain Injury

Conner Robert Adams1, Paolo Bazzigaluppi2, Tina L Beckett2, Jossana Bishay2, Joe Steinman1,3, Lydiane Hirschler4,5,6, Jan M Warnking4,6, Emmanuel L Barbier4,6, JoAnne McLaurin2,7, John G Sled1,3, and Bojana Stefanovic1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3Mouse Imaging Centre, Toronto, ON, Canada, 4Grenoble Institut des Neurosciences, UniversiteĢ Grenoble Alpes, Grenoble, France, 5Bruker Biospin MRI, Ettlingen, Germany, 6Inserm, U1216, Grenoble, France, 7Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

In-situ assessments of brain function following repeated mild traumatic brain injury (rmTBI) have yet to be seen. Herein, we report the first functional imaging study in the chronic phase of a mouse model of rmTBI. Pseudo-continuous arterial spin labelling MRI revealed a reduction in basal cerebral blood flow and cerebral reactivity, while electrophysiological recordings of evoked responses were greatly reduced in injured brain. Finally, immunohistochemical analysis of vascular endothelium, astrogliosis, and neurons was performed to investigate cellular populations.

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