Abstract #0083

Spatiotemporal development of spinal cord lesions in a primate model of multiple sclerosis

Jennifer A. Lefeuvre^1,2, Pascal Sati¹, Cecil Chern-Chyi Yen³, Seung Kwon A. Ha¹, Wen-Yang Chiang³, Mathieu D. Santin², Steven Jacobson⁴, Afonso C. Silva³, Stéphane Lehéricy², and Daniel D. Reich¹

¹NINDS, National Institutes of Health, bethesda, MD, United States, ²CENIR, Institut du Cerveau et de la Moelle epinière, Paris, France, ³National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ⁴National Institute of Neurological Disorders and Stroke, National Institutes of health, Bethesda, MD, United States

The spatiotemporal development of spinal cord (SC) lesions in multiple sclerosis (MS) is poorly understood, despite the high prevalence of these lesions and their important contribution to patient disability. In this study, we report for the first time the serial imaging of SC lesions in a nonhuman primate model of MS. The results demonstrated substantial clinical and imaging features shared between this animal model and human MS. In particular, we observed focal and subpial demyelinating lesions that appeared at disease onset and proceeded to affect much of the entire cord over the course of several weeks to months.

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