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Abstract #0082

Spatial Distribution of Multiple Sclerosis lesions in the Cervical Cord

Dominique Eden1, Charley Gros1, Atef Badji1,2, Sara Dupont1,3, Josefina Maranzano4, Ren Zhuoquiong5, Yaou Liu5,6, Jason Talbott3, Elise Bannier7,8, Anne Kerbrat9, Gilles Edan9,10, Pierre Labauge11, Virginie Callot12,13, Jean Pelletier12,13, Bernard Audoin12,14, Henitsoa Rasoanandrianina12,13, Paola Valsasina15, Massimo Filippi15, Rohit Bakshi16, Shahamat Tauhid16, Ferran Prados17, Marios Yiannakas17, Hugh Kearney17, Olga Ciccarelli17, Constantina A Treaba18, Caterina Mainero18, Russell Ouellette18,19, Tobias Granberg18,19, Sridar Narayanan4, and Julien Cohen-Adad1,20

1NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada, 2Faculty of Medicine, University of Montreal, Montreal, QC, Canada, 3Department of Radiology and Biomedical Imaging, Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA, United States, 4Montreal Neurological Institute, Montreal, QC, Canada, 5Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 6Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 7Department of Radiology, University Hospital of Rennes, Rennes, France, 8University of Rennes, INRIA, CNRS, INSERM, Rennes, France, 9University Rennes, INRIA, CNRS, INSERM, Rennes, France, 10Department of Neurology, University Hospital of Rennes, Rennes, France, 11University Hospital of Montpellier, Montpellier, France, 12CRMBM, CNRS, Aix-Marseille University, Marseille, France, 13CEMEREM, Hôpital de la Timone, AP-HM, Marseille, France, 14Department of Neurology, CHU Timone, APHM, Marseille, France, 15Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 16Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 17Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 18Massachusetts General Hospital, Boston, MA, United States, 19Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 20Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada

The study of the spatial distribution of multiple sclerosis (MS) lesions in the cervical spinal cord provides a means to further understand the disease pathophysiology. In this study we involve 358 patients across 7 sites, where cervical lesions were manually segmented. Using Spinal Cord Toolbox, lesion segmentations were registered to a common-space template and voxel-based lesion probability maps (LPMs) were computed across the patient population to assess lesion topography. Results revealed a predominance of lesions in the upper cord (C1-C3) and dorsal column, which confirms prior histopathology work and encourages further study of associations between cervical spine lesion volume and distribution with clinical status.

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