Meeting Banner
Abstract #0084

Thalamic lesions, thalamic volume and cognitive deficit in secondary progressive MS

Floriana De Angelis1, Jonathan Stutters1, Arman Eshaghi1, Ferran Prados1,2, Domenico Plantone1, Anisha Doshi1, Nevin John1, David MacManus1, Sebastien Ourselin2, Sue Pavitt3, Gavin Giovannoni4, Richard Parker5, Chris Weir5, Nigel Stallard6, Clive Hawkins7, Basil Sharrack8, Peter Connick9, Siddharthan Chandran9, Claudia Angela Gandini Wheeler-Kingshott 1,10,11, Frederik Barkhof2,12,13, and Jeremy Chataway1

1Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2Translational Imaging Group (TIG), Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, 3Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom, 4Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom, 5Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom, 6Statistics and Epidemiology, Division of Health Sciences, Warwick Medical School, University of Warwick, Warwick, United Kingdom, 7Keele University Medical School, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom, 8Department of Neurology, Royal Hallamshire Hospital, Sheffield, United Kingdom, 9Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 10Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 11Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy, 12National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, United Kingdom, 13Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands

We investigated the cross-sectional relationships between thalamic lesions (i.e. total thalamic lesion volume), thalamic volume, and cognitive deficit in 55 subjects with secondary progressive multiple sclerosis. We measured: total intracranial volume, T2 lesion volume (T2LV), thalamic volume, thalamic lesions, and symbol digit modalities test (SDMT). Thalamic lesions inversely correlated with thalamic volume and these two variables were independently associated with cognitive deficit as measured by SDMT. After adjusting for T2LV, thalamic volume was the strongest predictor of cognitive deficit. Thalamic lesions may have clinical relevance independent of thalamic volume and will be longitudinally investigated in a bigger sample size.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract Presentation Video